PHARMACOAT® (Hypromellose*)

* Instead of Hydroxypropyl Methylcellulose we changed its generic name to Hypromellose as from October, 2002.

Film coating was developed as a sub-coating for sugar coating in the 1950s, and film-coated tablets were introduced in the early 1970s. Since then, development work aimed at enhancing efficiency by increasing the production rate of film-coated tablets and reducing costs has been carried out along with efforts to increase the bioavailability of drugs. Film coating is now a well-established and effective technique. PHARMACOAT® was developed from hypromellose (also known as hydroxypropyl methylcellulose) in 1963, during the early days of film coating. It has been the subject of a continuous program of development and quality improvement. Film coatings of this type are now in widespread use throughout the world. PHARMACOAT® is also effective as a binder, because it does not interact with drugs and has high stability and non-ionic properties. In addition, PHARMACOAT® can be used in place of gelatin for hard capsule manufacturing because of its greater stability.

PHARMACOAT® Water-Soluble Film Coating Agent

(Hypromellose; USP)

  Grade Substitution Type Labeled Viscosity (mPa・s)*
PHARMACOAT® 603 2910 3
645 4.5
606 6
615 15

Note: * 2 wt.% aqueous solution at 20°C according to the USP measuring method.
PHARMACOAT® is also useful as a binder for tablets or granules.

SB-4 Sugar Coating Binder

(Hypromellose; USP)

  Substitution Type Labeled Viscosity (mPa・s)*
SB-4 2208 4

Note: * 2 wt.% aqueous solution at 20°C according to the USP method. SB-4 is useful as a binder for sugar coating.

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