Shin-Etsu AQOAT®

Shin-Etsu AQOAT®
(Hypromellose Acetate Succinate)

Shin-Etsu AQOAT® (hypromellose acetate succinate) is our second enteric coating material and it was developed for aqueous coating. Shin-Etsu AQOAT® was approved as a pharmaceutical excipient in Japan in 1987, and then in the United States and several European countries in 2001. In an aqueous system, a suspension containing Shin-Etsu AQOAT® (fine powder), triethyl citrate as a plasticizer, talc as an anti-tacking agent, and sodium lauryl sulfate as a wetting agent is typically used.
Shin-Etsu AQOAT® also shows excellent performance when it is used as a carrier for solid dispersions in order to enhance solubility of poorly soluble drugs.

Shin-Etsu AQOAT® Enteric Coating Agent (Aqueous System & Solvent System)

(Hypromellose Acetate Succinate; NF)

  Grade pH Solubility Application Form in Coating Operation
AS LF* ≧5.5 Aqueous Dispersion
MF* ≧6.0
HF* ≧6.8
LG ≧5.5 Organic Solvent
MG ≧6.0
HG ≧6.8

Note: * F is fine powder grade (av. particle size about 5μm).

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