Shin-Etsu AQOAT®
Shin-Etsu AQOAT®
(Hypromellose Acetate Succinate)
Shin-Etsu AQOAT® (hypromellose acetate succinate) is our second enteric coating material and it was developed for aqueous coating. Shin-Etsu AQOAT® was approved as a pharmaceutical excipient in Japan in 1987, and then in the United States and several European countries in 2001. In an aqueous system, a suspension containing Shin-Etsu AQOAT® (fine powder), triethyl citrate as a plasticizer, talc as an anti-tacking agent, and sodium lauryl sulfate as a wetting agent is typically used.
Shin-Etsu AQOAT® also shows excellent performance when it is used as a carrier for solid dispersions in order to enhance solubility of poorly soluble drugs.
Shin-Etsu AQOAT® Enteric Coating Agent (Aqueous System & Solvent System)
(Hypromellose Acetate Succinate; NF)
| Particle type | Fine* | Medium** | Coarse | |
|---|---|---|---|---|
| pH solubility |
≧5.5 | AS-LF | AS-LMP | AS-LG |
| ≧6.0 | AS-MF | AS-MMP | AS-MG | |
| ≧6.5 | AS-HF | AS-HMP | AS-HG | |
| Application | Aqueous coating | Solid dispersion(HME) | coating Solid dispersion(SD) | |
* D: NMT 10 μm, D90: NMT 20 μm by laser diffraction method ** D 50: 70 - 300 μm by laser diffraction method HME: Hot Melt Extrusion, SD: Spray Dry