Shin-Etsu

Shin-Etsu AQOAT®

Shin-Etsu AQOAT®
(Hypromellose Acetate Succinate)

Shin-Etsu AQOAT® (hypromellose acetate succinate) is our second enteric coating material and it was developed for aqueous coating. Shin-Etsu AQOAT® was approved as a pharmaceutical excipient in Japan in 1987. Shin-Etsu AQOAT® has been listed in USP/NF since 2005, in JP since 2012, also in EP since 2024. In an aqueous system, a suspension containing Shin-Etsu AQOAT® (fine powder), triethyl citrate as a plasticizer, talc as an anti-tacking agent, and sodium lauryl sulfate as a wetting agent is typically used.
Shin-Etsu AQOAT® also shows excellent performance when it is used as a carrier for solid dispersions in order to enhance solubility of poorly soluble drugs.

Shin-Etsu AQOAT® Enteric Coating Agent (Aqueous System & Solvent System)

(Hypromellose Acetate Succinate; NF)

  Particle type Fine* Medium** Coarse
pH
solubility
≧5.5 AS-LF AS-LMP AS-LG
≧6.0 AS-MF AS-MMP AS-MG
≧6.5 AS-HF AS-HMP AS-HG
Application Aqueous coating Solid dispersion(HME) coating
Solid dispersion(SD)

* D: NMT 10 μm, D90: NMT 20 μm by laser diffraction method
** D 50: 70 - 300 μm by laser diffraction method
HME: Hot Melt Extrusion, SD: Spray Dry

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