Shin-Etsu

L-HPC

L-HPC (Low-substituted hydroxypropylcellulose)

 

L-HPC is a low-substituted hydroxypropyl ether of cellulose within a small portion of the hydroxypropyl groups in the glucose unit. Whereas hydroxypropylcellulose (MS*=3) is soluble in both water and alcohol, L-HPC (MS*=0.2-0.4) swells in water and is insoluble.
L-HPC is used as a binder and a disintegrant for solid dosage forms. It was brought onto the market in 1977, and then listed in the JP in 1986, in the NF in 1990 and in the EP in 2016. This product exhibits a wide range of compatibility with many active substances. It is a suitable binder and disintegrant for a formulation study.
We have developed a NBD for the L-HPC family. This is chemically identical to the current L-HPC grades, but particle shape is physically designed to significantly improve binding capability.

MS*: molar substitution.

L-HPC Disintegrant with Binding Properties

(Low-Substituted Hydroxypropyl Cellulose; NF)

LH series

Grade Particle
appearance
Characteristics Hydroxypropoxy content(%) Mean particle size(μm) 90 % cumulated particle size(μm) Typical application
LH-11 Most fibrous Highly anti-capping effect 11 55 175 Direct compression, Wet granulation (anti-capping)
LH-21 Moderately fibrous Regular grade 11 45 135 Direct compression, Wet granulation
LH-22 Moderately fibrous High swelling speed 8 45 135 Direct compression, Wet granulation (sometimes better disintegration)
LH-B1 Non fibrous/High density Highly swelling force 11 55 125 Fluid-bed granulation, direct compression for high-load formulation
LH-31 Micronized High binding strength 11 20 70 Pellet extrusion, layering
LH-32 Micronized High binding strength 8 20 70 Pellet extrusion, layering

NBD series

Grade Particle appearance Characteristics Hydroxypropoxy content(%) Mean particle size(μm) 90 % cumulated particle size(μm) Typical application
NBD-022 Short fiber (uniformly) High swelling speed 8 45 100 Oral disintegrating tablet, Direct compression
NBD-021 Short fiber (uniformly) Regular garde 11 45 100 Direct compression, Wet granulation
NBD-020 Short fiber (uniformly) High binding strength 14 45 100 Wet granulation

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