PDF version (1.67MB) PIN code is necessary Metolose (Hypromellose* & Methylcellulose) *  Instead of Hydroxypropyl Methylcellulose we changed its generic name to Hypromellose as from October, 2002. Shin-Etsu Chemical started production of water-soluble cellulose ethers in 1962 under the trade name Metolose. Metolose consists of methylcellulose and hypromellose, each of which is available in several grades of viscosity. In the manufacturing process, highly purified natural pulp is etherified with methyl chloride or with the combination of methyl chloride and propylene oxide to form a water-soluble, non-ionic cellulose ether. No animal resources are used in the production of Metolose. Metolose can be used as a binder for solid medicaments such as tablets and granules. It also serves a variety of functions, for examples, in enhancing water retention, thickening, acting as a protective colloid due to its surface activity, sustaining release, and film formation. Metolose is also used as a non-digestive fiber for dietary supplements. PDF version (1.50MB) PIN code is necessary Metolose SR (Hypromellose*) *  Instead of Hydroxypropyl Methylcellulose we changed its generic name to Hypromellose as from October, 2002. Metolose SR is designed exclusively for a hydrophilic matrix agent. It has tighter specifications compared to the regular Metolose grades. The hydrophilic matrix system is the simplest sustained-release technology for oral dosage forms, consisting essentially of a drug and a water-soluble, highly viscous polymer. Metolose SR has a high level of consistency in its product quality. Metolose  Binder and Thickening Agent (Hypromellose; USP & Methylcellulose; USP)    Type Viscosity Grade* (mPa･s) Substitution Type Methoxy Content(%) Hydroxypropoxy Content(%) Metolose SM 4,15,25,100,400 1500,4000 (Methylcellulose) 26.0-33.0 - 60SH 50,4000,10000 2910 28.0-30.0 7.0-12.0 65SH 50,400,4000 2906 27.0-30.0 4.0-7.5 90SH 4000,15000,100000 2208 19.0-24.0 4.0-12.0 Note: * 2 wt.% aqueous solution at 20oC according to the USP measuring method.   Metolose SR grade   Sustained Release Usage (Hypromellose; USP)    Type Viscosity Grade* (mPa･s) Substitution Type Methoxy Content(%) Hydroxypropoxy Content(%) Particle size(%) Metolose SR 90SH 100SR 4000SR 15000SR 100000SR 2208 22.0-24.0 8.0-12.0 150 m on less than 5.0% Note: * 2 wt.% aqueous solution at 20oC according to the USP measuring method. The degree of substitution and powder properties (i.e.; particle size, etc.) of Metolose SR grades are controlled to a limited range which is suitable for sustained release preparations from the view point of functionality and processability. Metolose SR grades are suitable for direct compression and wet granulation.