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Shin-Etsu Chemical Co., Ltd.
Organic Chemicals Division
Cellulose & Pharmaceutical Exciplents Department
Pharmacoat
Metolose
L-HPC
HPMCP
Shin-Etsu AQOAT
Metolose
 
Metolose
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Metolose (Hypromellose* & Methylcellulose)
Instead of Hydroxypropyl Methylcellulose we changed its generic name to Hypromellose as from October, 2002.
Shin-Etsu Chemical begun to produce water-soluble cellulose ethers in 1962, with the trade name "Metolose". Consisting of methylcellulose and hydroxypropyl methylcellulose, each available in several grades of different viscosity. Highly purified natural pulp is etherified with methyl chloride or with the combination of methyl chloride and propylene oxide to form a water-soluble, non-ionic cellulose ether. There is no animal resources used in the production, and it is also regarded as a non-digestive fiber.
"Metolose" can be used as a binder for solid medicaments such as tablets and granules. It also provides a variety of functions such as water retention, thickening, protective colloid, surface activity, sustained release, film formation, etc.
Metolose SR
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Metolose SR (Hypromellose*)
Instead of Hydroxypropyl Methylcellulose we changed its generic name to Hypromellose as from October, 2002.
"Metolose SR" is exclusively designed for a hydrophilic matrix agent having tighter specifications, which is especially suitable for this matrix system.
The hydrophilic matrix system is the simplest sustained release technology for oral dosage forms, consisting essentially of a drug and a water-soluble high viscous polymer.
"Metolose SR" provides a genuine consistency in the products.
Metolose  Binder and Thickening Agent
(Hypromellose; USP & Methylcellulose; USP)
   Type Viscosity Grade* (mPa・s) Substitution Type Methoxyl
Content(%)
Hydroxypropoxyl
Content(%)
Metolose SM 4,15,25,100,400
1500,4000
(Methylcellulose) 27.5-31.5 -
60SH 50,4000,10000 2910 28.0-30.0 7.0-12.0
65SH 50,400,4000 2906 27.0-30.0 4.0-7.5
90SH 4000,15000,100000 2208 19.0-24.0 4.0-12.0
Note: * 2 wt.% aqueous solution at 20oC according to the USP measuring method.
 
Metolose SR grade   Sustained Release Usage
(Hypromellose; USP)
   Type Viscosity Grade* (mPa・s) Substitution Type Methoxyl
Content(%)
Hydroxypropoxyl
Content(%)
Particle size(%)
Metolose SR 90SH 100SR
4000SR
15000SR
100000SR
2208 22.0-24.0 8.0-12.0 150 micrometerm on
less than 5.0%
Note: * 2 wt.% aqueous solution at 20oC according to the USP measuring method.
The degree of substitution and powder properties (i.e.; particle size, etc.) of Metolose SR grades are controlled to a limited range which is suitable for sustained release preparations from the view point of functionality and processability.
Metolose SR grades are suitable for direct compression and wet granulation.
 
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