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 L-HPC
(Low-substituted hydroxypropylcellulose) |
| MS*: molar substitution. |
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L-HPC is a low-substituted hydroxypropyl ether of cellulose within a small portion of the hydroxypropyl groups in the glucose unit. Whereas hydroxypropylcellulose (MS*=3) is soluble in both water and alcohol, L-HPC (MS*=0.2-0.4) swells in water and is insoluble.
L-HPC is used as a binder and a disintegrant for solid medicaments. It was brought onto the market in 1977, and then listed in the JP in 1986 and in the NF in 1990. This product exhibits a wide range of compatibility with many active substances. It is a suitable binder and disintegrant for a formulation study.
We have developed a new grade NBD for the L-HPC family. This is chemically identical to the current L-HPC grades, but particle shape is physically designed to significantly improve binding capability.
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L-HPC Disintegrant with Binding Properties
(Low-Substituted Hydroxypropyl Cellulose; NF) |
| LH series |
| Grade |
Particle appearance |
Characteristics |
Hydroxypropoxy content(%) |
Mean particle size(μm) |
90% cumulated particle size(μm) |
Typical application |
| LH-11 |
Most fibrous |
Highly anti-capping effect |
11 |
55 |
175 |
Direct compression, Wet granulation （anti-capping） |
| LH-21 |
Moderately fibrous |
Regular grade |
11 |
45 |
135 |
Direct compression, Wet granulation |
| LH-22 |
Moderately fibrous |
High swelling speed |
8 |
45 |
135 |
Direct compression, Wet granulation (sometimes better disintegration) |
| LH-B1 |
Non fibrous/High density |
Highly swelling force |
11 |
55 |
125 |
Fluid-bed granulation, direct compression for high-load formulation |
| LH-31 |
Micronized |
High binding strength |
11 |
20 |
70 |
Pellet extrusion, layering |
| LH-32 |
Micronized |
High binding strength |
8 |
20 |
70 |
Pellet extrusion, layering |
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NBD series |
| Grade |
Particle appearance |
Characteristics |
Hydroxypropoxy content(%) |
Mean particle size(μm) |
90% cumulated particle size(μm) |
Typical application |
| NBD-022 |
Short fiber(uniformly) |
High swelling speed |
8 |
45 |
100 |
Oral disintegrating tablet, Direct compression |
| NBD-021 |
Short fiber (uniformly) |
Regular garde |
11 |
45 |
100 |
Direct compression, Wet granulation |
| NBD-020 |
Short fiber (uniformly) |
High binding strength |
14 |
45 |
100 |
Wet granulation |
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