Shin-Etsu

PDF version (871KB) PIN code is necessary	L-HPC (Low-substituted hydroxypropylcellulose)
	MS*: molar substitution.
	"L-HPC" is a low-substituted hydroxypropyl ether of cellulose whithin quite a small portion of the hydroxypropyl groups in the glucose unit. While hydroxypropylcellulose (MS=3) is soluble in both water and alcohol, "L-HPC" (MS=0.2-0.4) swells in water and is insoluble. "L-HPC" is used as a binder and a disintegrant for solid medicaments. It was brought onto the market in 1977, and then listed in the JP in 1986 and in the NF in 1990. The unique character of this product exhibits a wide range of compatibility with many active substances. This is a suitable binder and disintegrant for a formulation study. A new high density grade of "LH-B1" which has been introduced to the list of L-HPC shows an improved flowability and it is suitable for direct compression. It is applicable to a L-HPC high loading formulation.

L-HPC Disintegrant with Binding Properties
(Low-Substituted Hydroxypropyl Cellulose; NF)

	Grade	Particle size* (micrometer)	Particle type	Hydroxypropoxyl Content(%)	Method of Application
LH	11*	50	Highly fibrous	10.0-12.9	Direct compression (anti-capping)
	21	40	Moderately fibrous	10.0-12.9	Regular grade (dry-mixing, wet granulation)
	22	40	Moderately fibrous	7.0-9.9	Lower hydroxypropyl (sometimes better disintegration)
	B1	50	Non fibrous	10.0-12.9	Direct compression, high loading formulation
	31	20	Micronized	10.0-12.9	Micronized grade (extrusion, layering)
	32	20	Micronized	7.0-9.9	Micronized grade (extrusion, layering)

Note)* : These show typical values, not specifications.