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Shin-Etsu Chemical Co., Ltd.
Organic Chemicals Division
Cellulose & Pharmaceutical Exciplents Department
Pharmacoat
Metolose
L-HPC
HPMCP
Shin-Etsu AQOAT

HPMCP (Hypromellose Phthalate)
 

HPMCP
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HPMCP (Hypromellose Phthalate)
"HPMCP" (hydroxypropyl methylcellulose phthalate), since its production start into the market in 1971 as an enteric coating, has been demonstrated to be effective by many researchers. It is widely used as an enteric coating agent by the pharmaceutical industry. "HPMCP" had been admitted into the NF, EP and JP.
It can dissolve at pH 5-5.5 and be controlled by varying the phthalyl content. Two types of different pH solubility, HP-55 and HP-50, are available. A suitable grade of "HPMCP" for a particular purpose should be selected in accordance with the properties and formulations.

  
HPMCP  
Enteric Coating Agent (Solvent System)
(Hypromellose Phthalate; NF)   
   Grade Nominal Phthalyl
Content
pH Solubility Labeled Viscosity (cSt)*
HPMCP 50 24% >=5.0 55
55 31% >=5.5 40
55S 170

Note: * 10 wt.% in a mixture of equal weights of Methanol and Methylene Chloride according to the USP/NF measuring method.
 

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