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Shin-Etsu Chemical Co., Ltd.
Organic Chemicals Division
Cellulose & Pharmaceutical Exciplents Department
Pharmacoat
Metolose
L-HPC
HPMCP
Shin-Etsu AQOAT
Technical infromaiton

HPMCP (Hypromellose Phthalate)
 

HPMCP
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HPMCP (Hypromellose Phthalate)
Since its introduction into the market in 1971 as an enteric coating, HPMCP (hypromellose phthalate) has been demonstrated to be effective by many researchers. It is widely used by the pharmaceutical industry. HPMCP has been admitted into the NF, EP and JP.
It dissolves at pH 5-5.5 and this property can be controlled by varying the phthalyl content. Two grades of different pH solubility, HP-55 and HP-50, are available. The grade of HPMCP appropriate for a particular purpose should be selected in accordance with its properties and formulations.

  
HPMCP  
Enteric Coating Agent (Solvent System)
(Hypromellose Phthalate; NF)   
   Grade Nominal Phthalyl
Content
pH Solubility Labeled Viscosity (cSt)*
HPMCP 50 24% >=5.0 55
55 31% >=5.5 40
55S 170

Note: * 10 wt.% in a mixture of equal weights of Methanol and Methylene Chloride according to the USP/NF measuring method.
 

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