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Shin-Etsu Chemical Co., Ltd.
Organic Chemicals Division
Cellulose & Pharmaceutical Exciplents Department
Pharmacoat
Metolose
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Shin-Etsu AQOAT
Shin-Etsu AQOAT (HPMCAS)
 
Shin-Etsu AQOAT
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Shin-Etsu AQOAT  (Hypromellose Acetate Succinate*)

*Instead of Hydroxypropyl Methylcellulose Acetate Succinate we will change its generic name to Hypromellose Acetate Succinate as from January, 2006.

"Shin-Etsu AQOAT" (Hypromellose Acetate Succinate) is a new enteric coating material developed mainly for aqueous coating by Shin-Etsu Chemical. "Shin-Etsu AQOAT" was approved as a pharmaceutical excipient first in Japan in 1987, and then in the United States and several European countries in 2001.
In an aqueous system, a suspension of the "Shin-Etsu AQOAT" fine powder, triethyl citrate as a plasticizer and water is applied for coating.
"Shin-Etsu AQOAT" has the unique character of a low glass transition temperature, which can give a solid dispersion for poorly soluble drugs.

 
Shin-Etsu AQOAT  
Enteric Coating Agent (Aqueous System & Solvent System)
(Hypromellose Acetate Succinate; NF)
    Grade pH Solubility Application Form in Coating Operation
AS LF* >=5.5 Aqueous Dispersion
MF* >=6.0
HF* >=6.8
LG >=5.5 Organic Solvent
MG >=6.0
HG >=6.8

Note: * F is fine powder grade (av. particle size about 5microm).
   

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