Shin-Etsu

PDF version (1.24MB)
PIN code is necessary

Shin-Etsu AQOAT (Hypromellose Acetate Succinate*)

Shin-Etsu AQOAT (hypromellose acetate succinate) is our second enteric coating material and it was developed for aqueous coating. Shin-Etsu AQOAT was approved as a pharmaceutical excipient in Japan in 1987, and then in the United States and several European countries in 2001. In an aqueous system, a suspension containing Shin-Etsu AQOAT (fine powder), triethyl citrate as a plasticizer, talc as an anti-tacking agent, and sodium lauryl sulfate as a wetting agent is typically used.
Shin-Etsu AQOAT also shows excellent performance when it is used as a carrier for solid dispersions in order to enhance solubility of poorly soluble drugs.

Shin-Etsu AQOAT Enteric Coating Agent (Aqueous System & Solvent System)
(Hypromellose Acetate Succinate; NF)

	Grade	pH Solubility	Application Form in Coating Operation
AS	LF*	5.5	Aqueous Dispersion
	MF*	6.0
	HF*	6.8
	LG	5.5	Organic Solvent
	MG	6.0
	HG	6.8

Note: * F is fine powder grade (av. particle size about 5m).